Cube bread into pieces about 2x3 inches each.Arrange cubed bread evenly in a buttered 9 by 13-inch flat baking dish.In a large bowl, combine the eggs, half-and-half, milk, sugar, vanilla, cinnamon, nutmeg and beat with a rotary beater or whisk until well blended. Pour mixture over the bread making sure all are covered evenly with the milk-egg mixture. Spoon some of the mixture in between the cubes. Cover with foil and refrigerate overnight.
The next day, preheat oven to 350 degrees. Bake casserole (covered) for about 20 minutes. remove foil and bake about 15 minutes or until knife comes out clean