Anna's Beef and Biscuit Casserole

Anna's Beef And Biscuit Casserole Recipe

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Anna Vandenhazel


The original recipe is called "John Wayne Casserole", but it called for green peppers and chilis, which neither my husband nor I can eat, so I felt it was only fair to change the title as well.

The original recipe also called for 2 Roma tomatoes, but since I had no ripe tomatoes of any kind I used the tomato sauce instead, and my husband loved it!


☆☆☆☆☆ 0 votes

25 Min
35 Min


  • 2 lb
    ground beef
  • 1 oz
    taco seasoning mix packet
  • 1 can(s)
    tomato sauce (8 oz)
  • 3/4 c
  • 1/2 c
    sour cream
  • 1/2 c
  • 1 c
    cheddar cheese, shredded
  • 2 c
    biscuit mix (bisquick works well)
  • 1 c

How to Make Anna's Beef and Biscuit Casserole


  1. Preheat oven to 325 degrees.
  2. Spray a 9x13" pan or baking dish with non-stick cooking spray.
  3. Brown ground beef until no longer pink, then add taco seasoning, tomato sauce, and 3/4 cup water and let simmer for 3-4 minutes.
  4. In a medium bowl, mix sour cream, mayonnaise, and half of the cheese together and set aside.
  5. In another bowl, mix together biscuit mix and 1 cup water to make a soft dough. Press into bottom and 1/2" up the sides of greased 9x13" pan.
  6. On top of the biscuit dough, layer the remaining ingredients in this order: ground beef mixture, sour cream mixture, and remaining cheddar cheese.
  7. Bake for 30-35 minutes, or until edges are lightly browned.

Printable Recipe Card

About Anna's Beef and Biscuit Casserole

Course/Dish: Beef
Main Ingredient: Beef
Regional Style: Mexican
Hashtags: #Bisquick, #beef

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