Heat oven to 375. Lightly spray a rimmed 10" x 15" baking sheet w/ cooking spray. In lg bowl, combine flour, sugar, baking soda, and pumpkin pie spice.
Stir in pumpkin puree and eggs. Mix well. Pour mix onto baking sheet, spreading it out evenly. Bake about 15 mins, or until a toothpick inserted in center comes out clean.
Invert onto a clean kitchen towel. Sprinkle w/ 2 tbsp powdered sugar. Roll up, jelly-roll style, starting from the short end. Let cool. In bowl, beat cream cheese, butter, vanilla and remaining powdered sugar until smooth. Unroll cake gently. Spread cream cheese mix onto cake and gently re-roll w/out towel. Refrigerate until serving. Cut into slices.