Preheat oven to 350 degrees. Mix bead crumbs, 2 TBs of grated cheese, 2 TBS melted butter amd 1/2 tsp of Italian seasoning in small bowl. Set aside. Cut up any large broccoli or califlower florets into bite-sized pieces.
Melt 2 Tbs butter in large skillet on medium heat. Add onion, cook and stir about 5 minutes or until tender. Stir in flour, remaining 1 tsp Italian seasoning, garlic, salt and pepper. Add milk, cook and stir until thickened and bubbly. Add cream cheese and remaining 1/4 cup grated cheese; cook and stir until cream cheese is melted. Add vegetables, toss gently to coat. Spoon into 2 quart baking dish. Sprinkle top evenly with crumb mixture.
Bake 40 minutes until heated through and top is lighty browned.