Preheat oven to 450°F. Coat an 8-inch square baking dish with cooking spray.
In a large skillet, brown ground beef with onion powder, garlic powder, and pepper over high heat, stirring to break up the beef. Drain off any fat then add the ketchup and cheese; mix well and pour into prepared baking dish.
Place biscuits over top and bake 8 to 10 minutes, or until biscuits are golden and cooked through.