Whisk preserves and 2/3 cup orange juice in a 2-cup measuring cup. Place cream cheese and 4 T. orange juice in a large bowl and beat together until smooth. Add cream, sugar, and vanilla and beat to soft peaks.
Hull and slice strawberries. Spread 1/2 cup preserve mixture over bottom of 13x9-inch glass baking dish. Arrange slices of pound cake to cover bottom of dish. Spoon 3/4 cup preserve mixture over pound cake, then spread 2 1/2 cups cream cheese mixture over the pound cake. Arrange 2 cups sliced strawberries over cream cheese mixture. Repeat layering with remaining pound cake, preserve mixture, and cream cheese mixture. Cover with plastic and chill at least 8 hours or overnight.
Arrange the rest of the strawberries over the top just before serving.
NOTE: Most Tiramisu recipes use ladyfingers. They are hard to find in my small town, so I started using pound cake and I find that I like that better. You can use ladyfingers if you prefer.